The Gold Standard in Transfection. Accelerated.
When your research reaches the clinical frontier, don’t let delivery be your bottleneck.
In the competitive landscapes of HKU’s stem cell labs and the Science Park’s biotech startups, Polyplus-transfection® is the undisputed name in nucleic acid delivery. Alpha Labs Limited brings you the industry-leading reagents that bridge the gap from benchtop discovery to large-scale manufacturing. From the world-renowned jetOPTIMUS® for everyday DNA transfection to the clinical-grade PEIpro® for viral vector production, we provide the scalability and efficiency required by Hong Kong’s top innovators.
Stop settling for low yields and high toxicity. Whether you are working with mRNA, CRISPR/Cas9, or viral vectors (AAV, Lentivirus), Polyplus solutions are engineered for maximum titer and minimal stress.
The Polyplus Edge: From Discovery to Clinic
1. Research Grade Transfection (In Vitro)
2. Bioproduction & Viral Vector Manufacturing
3. In Vivo Nucleic Acid Delivery
4. Protein Production in Suspension Cells
5. Large-Scale Viral Vector Manufacturing
In the competitive landscapes of HKU’s stem cell labs and the Science Park’s biotech startups, Polyplus-transfection® is the undisputed name in nucleic acid delivery. Alpha Labs Limited brings you the industry-leading reagents that bridge the gap from benchtop discovery to large-scale manufacturing. From the world-renowned jetOPTIMUS® for everyday DNA transfection to the clinical-grade PEIpro® for viral vector production, we provide the scalability and efficiency required by Hong Kong’s top innovators.
Stop settling for low yields and high toxicity. Whether you are working with mRNA, CRISPR/Cas9, or viral vectors (AAV, Lentivirus), Polyplus solutions are engineered for maximum titer and minimal stress.
The Polyplus Edge: From Discovery to Clinic
1. Research Grade Transfection (In Vitro)
- jetPRIME®: The versatile gold standard for daily DNA and siRNA co-transfection, offering high efficiency and low toxicity in routine cell lines.
- jetOPTIMUS®: A best-in-class nanotechnology reagent designed specifically for hard-to-transfect cells, including primary cells and stem cells, without compromising viability.
- jetMESSENGER®: Specialized mRNA transfection reagent that enables high efficiency in slow-dividing or "difficult" cells by bypassing the nuclear envelope.
2. Bioproduction & Viral Vector Manufacturing
- PEIpro®: The most cited linear PEI-based reagent for scalable viral vector production. It is available in HQ (High Quality) and GMP grades to support your transition from research to clinical trials.
- FectoVIR®-AAV: A next-generation reagent optimized specifically to boost AAV titers and simplify the scale-up process in suspension cell systems.
- FectoPRO®: Engineered for high-yield transient protein and antibody expression in CHO and HEK-293 suspension cultures.
3. In Vivo Nucleic Acid Delivery
- in vivo-jetPEI®: The most reliable non-viral vector for animal studies, currently utilized in numerous human clinical trials for gene therapy and mRNA vaccine development.
4. Protein Production in Suspension Cells
- FectoPRO®: This is the most powerful reagent for transient protein and antibody expression in CHO and HEK-293 suspension cells. It is specifically designed to achieve amazing yields with low DNA concentrations, making it cost-effective for larger volumes.
- FectoCHO® Expression System: A complete kit (including reagent and chemically defined media) specifically optimized for CHO cells, ensuring high-density growth and superior protein quality.
5. Large-Scale Viral Vector Manufacturing
- FectoVIR®-AAV: While PEIpro is the gold standard for general use, FectoVIR-AAV was developed specifically for AAV production. It reduces the amount of DNA needed and can increase viral titers by up to 10-fold in suspension bioreactors.
- PEIpro®-GMP: For your clinical-stage customers at the Science Park, you can supply the GMP-grade version. This is the exact same chemistry as the research-grade PEIpro but manufactured under strict regulatory compliance for use in human gene therapy.
Need a quote or a technical protocol for Polyplus products? WhatsApp us at +852 9662 0635 for immediate local support."
High transfection efficiency starts with a stable cell environment. Ensure your cells are at peak performance using BioLamina’s Biolaminin® substrates before starting your jetOPTIMUS® protocol.
High transfection efficiency starts with a stable cell environment. Ensure your cells are at peak performance using BioLamina’s Biolaminin® substrates before starting your jetOPTIMUS® protocol.
F&Q
- Q: Can I use jetOPTIMUS® for cells grown in antibiotic-supplemented media?
- A: Yes. Unlike many other reagents, jetOPTIMUS® is compatible with media containing penicillin/streptomycin, meaning you don't have to change your media before or after transfection.
- Q: What is the primary difference between PEIpro® and standard branched PEI?
- A: PEIpro® is a highly characterized, linear polyethylenimine with a narrow molecular weight distribution. This results in significantly higher viral titers and better reproducibility compared to "home-brew" or lower-grade PEI.
- Q: Is jetMESSENGER® suitable for co-transfection of DNA and mRNA?
- A: jetMESSENGER® is optimized specifically for mRNA. For co-transfection, we generally recommend using jetOPTIMUS®, but for high-efficiency mRNA delivery in neurons or stem cells, jetMESSENGER® is the superior standalone choice.
